I get them every three months. 2011;9(1):32-40. Bloods are fine. Copy link to clipboard. I have one of those ridges around my teeth that I take zometa every six months (3 years now since I had Wife needs implants but has had bisphosphonates (Zometa 4 This can cause us to lose bone density younger and need early intervention. • 4 mg as retreatment after a minimum of 7 days. Half also were given infusions of Zometa once every six months. I am taking Zometa by infusion every 6 months, following breast cancer surgery (mastectomy) and chemo, augmented by - Answered by a verified Health Professional We use cookies to give you the best possible experience on our website. I've had 3 now. Zoledronic acid infusion for prevention and treatment of osteoporosis. ABCSG-12 Substudy. J Support Oncol. The recommended dose of Zometa in patients with multiple myeloma and metastatic bone lesions from solid tumors for patients with creatinine clearance (CrCl) greater than 60 mL/min is 4 mg infused over no less than 15 minutes every 3 to 4 weeks. Both Zometa and Aredia are given intravenously, usually every 4 weeks. By then, only 6 … I am sure your oncologist will consider something else if you have more problems. One key to this, I believe, is the length of time the infusion takes. I had the first doses last year with my chemo and I've just had the first solo one on Tuesday. 5. The American Society of Clinical Oncology recommends that people in this group receive Zometa once every 6 months. As studies have shown that women on Zometa had less reoccurance than ones that were not on it. I wasn't offered choice but have since learnt that when using the tablet form it has to be taken on empty stomach with full glass of water then stand or sit upright for 30 mins ! It is effective in reducing complications arising from metastatic bone disease in this patient population, with a clinical pro … It swelled up after my 2nd one and no one knows why.” Really sorry to hear about the side effects you and some others have had. The primary end point of the study was disease-free survival. I have had one infusion so far and had extreme fever chills shakes about 18 hours after. I am now on zoledronic acid every 6 months for 3years. Read the Patient Information Leaflet if available from your pharmacist before you start receiving Posts : 1857. We are all different and I thought I'd add a positive report. • 4 mg as a single-use intravenous infusion over no less than 15 minutes. I take zometa every six months (3 years now since I had breast cancer). The zometa infusions are to strengthen your bones. Densitometry was performed annually. I did the zometa infusions. Zometa is Very tired and usually down in bed for two days. Common Zometa side effects may include:nausea, vomiting, diarrhea, constipation;bone pain, muscle or joint pain;fever or other flu symptoms;pain in your arms or legs;red or puffy eyes;headache, tiredness; ortrouble breathing. I had any dental work done before started (I actually needed to bring dental clearance to my first infusion). This solution is ready-to-use and may be administered directly to the patient without further preparation. Zometa is administered by injection in a doctors office or clinic. Medicare Part B normally covers infusion therapy but your doctor must be sure your claim is properly coded with a specific diagnosis. I've gone for Zometa infusions every month for the past year and have had no side effects since that first one. Zometa is considered the first-line option in the United States given its market availability. Patients and methods: A prospective, observational study in patients with OI, osteoporosis or osteopenia (T score <-2) who were administered zoledronic acid infusions (4mg IV) every 6 months for three years and annually thereafter. I'm having zolendronic acid as infusion every 6 months, to reduce the risk of recurrence. 4. I've had two so far and have not experienced any bad side effects. Prolia (denosumab) and Zometa (zoledronic acid) are used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause. I needed a dental exam, chest x-ray, bone scan (used the ones for the mastectomy) and have a kidney function test before each infusion. My transfusion nurse mentioned a 3 or 6 month option, for now I want to remain on the 1 month as while I'm there I can get other things accomplished. I would try the next one and see how you react . Medicaid/HIM – 3 months (one infusion every 3 weeks) Commercial – 6 months or to the member’s renewal date, whichever is longer E. Prostate/Breast Cancer - Fracture Prevention (off-label) (must meet all): 1. If you have questions about the … Two years after their treatments … Yes, I have a Zometa infusion every six months. What is your opinion? I will take it monthly for 6 months, then once every 3 months for 2.5 years. It’s a low percentage reduction to add to your overall recurrence percentage but 2)it is also bone strengthener as I/you take Anastrozole. I've had a CT scan and everything is fine. I am taking zometa; my doctor says I will have the infusion every 6 months for 3 years, then stop. Zometa is recommended every six months for three to five years, while Bonefos (clodronate), an oral medication, can be taken daily for two to three years. Black DM, Delmas PD, Eastell R, et al. Is anyone else doing this? 4 mg IV infusion over at least 15 minutes and given every 6 months appears effective at increasing or preserving bone mineral density (BMD) and reducing fracture risk; calcium and vitamin D is supplemented if dietary intake is inadequate. If you are having zoledronic acid to reduce pain or strengthen your bones, your doctor will talk to you about how long you may need to have it for. Best wishes.-Madlyn Bottles of Zometa ready-to-use solution for infusion contain overfill allowing for the administration of 100 mL of solution (equivalent to 4 mg zoledronic acid). For single use only. If you are having zoledronic acid to help prevent the cancer coming back, you will have an infusion once every 6 months for 3 to 5 years. Zometa has helped reduced my bone pain and it is easily administered with minimal side effects. My oncologist had me start on Zometa every 6 months even though my bone density is excellent as a recent study has shown it can help prevent bone mets. Zometa: Coverage is provided for 6 months and may be renewed ... 4 mg every 6 months Prevention of androgen deprivation-induced bone loss in prostate cancer 4 mg – 5mg every 3 to 12 months All other indications 4 mg IV every 3 to 4 weeks Reclast Active Paget’s Disease 5 mg x … A second interim analysis revealed that a pre-specified boundary for lack of benefit had been crossed. The optimal duration of therapy is not known. Comment from: arloboy, 55-64 on Treatment for 2-5 years (Patient) Published: October 27. I was randomized into the Zoledronic acid (Zometa) arm and receive it with my chemo. Request is for Zometa; Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer. However, it can be used to treat bone disease in patients who have cancer. Zoledronic acid is in a class of medications called bisphosphonates. It works by slowing bone breakdown,... The thing is the right side of my tummy is swollen from just above my belly button and over to my right side. You may need to have it for as long as it is working. Jaw problems are rare and they are associated with invasive dental procedures- … The women were treated for three years and studied for two more. Any drilling could cause jaw necrosis. My first Zometa infusion. Hi Cupotea I'm on zoledronic infusions and as such have an infusion every 6 months .. My plan is for 3 year poss 5 yr and I'm due no 4 at end of month . Post-menopausal breast cancer patients will receive letrozole 2.5 mg daily for the treatment of breast cancer and will be randomized to a treatment group to receive either upfront zoledronic acid 4 mg IV 15-minute infusion every 6 months or delayed start zoledronic acid 4 mg IV 15-minute infusion every 6 months. Zoledronic acid belongs to a class of drugs called bisphosphonates. It was every six months for three years. I have had 5 more and felt fine after each one. Zoledronic acid 4 mg administered as a 15-minute infusion every 3-4 weeks is effective and well tolerated in the treatment of patients with breast cancer metastatic to bone. In the case of the medications denosumab and zoledronic acid, costs also include those associated with treatment administration by a healthcare professional. In ABCSG-12, with a planned enrollment of 1,800, premenopausal patients with stage I-II hormone-receptor-positive breast cancer are treated for 3 years with the LHRH analogue goserelin (Zoladex), 3.6 mg subcutaneously every 28 days, and randomized to one of four treatment groups: tamoxifen 20 mg/d plus placebo or IV zoledronic acid (4 mg every 6 months), or the … Multiple myeloma and bone metastasis from solid tumors (2.2) • 4 mg as a single-use intravenous infusion over no less than 15 minutes every 3-4 weeks for patients with creatinine clearance of greater than 60 mL/min. The zoledronic acid was administered every 3 to 4 weeks for 6 doses and then every 3 to 6 months to complete 5 years of treatment. Comment from: antizometa, 35-44 on Treatment for 1-6 months (Patient) Published: June 02. My first Zometa infusion was in July 2008. A study suggests that after being treated with the regular dose of Zometa and/or Aredia for a year, women with bone metastases can get Zometa every 12 weeks and still get the same benefits from the … Zoledronic acid for primary breast cancer | Breast Cancer Now Bone metastases can cause bone pain, bone fractures, and other complications. once a month. Zometa usually starts out by getting a dose every month, but after a while is spread out to every six weeks and then every 12 weeks. Joined : Jul 2011. Fever, nausea, constipation, anemia, and shortness of breath are the most frequently reported side effects. ...A lowering in the levels of certain electrolytes such as phosphate, potassium, and magnesium may occur.Some people report insomnia, anxiety or confusion, coughing, and skeletal pain with Zometa.More items... In some cases because we are special we get to lose our estrogen earlier than normal, and more completely. 3. Bisphosphonates are commonly used to prevent these complications in patients with bone metastases, but the drugs themselves can have side effects. About 8 hours later, I came down with a 102 degree fever, chills, body aches, and mild nausea. Zometa is also used to increase bone mass in men with osteoporosis. 4 mg IV every 6 months Prevention of androgen deprivation-induced bone loss in prostate cancer 4 mg IV every 3 months ... Trial Evaluating Infusion Duration of Zoledronic Acid in Multiple Myeloma Patients (the ZMAX Trial). Make sure you get your dental work done first before the infusion. It was explained to me that zometa does two things 1) studies show it helps to keep the cancer from coming back in your bones. For osteoporosis prevention in men with prostate cancer receiving androgen deprivation therapy†. 2 Likes. Bisphosphonates interfere with the breakdown of bone tissue that results when cancer cells form metastases in the bone. I had an awful, restless night but felt pretty much back to normal by mid-morning. My oncologist says this often happens. According to the ASCO/CCO guidelines, the drugs would be dosed as follows: 1. Posted 5/27/2012 9:53 AM (GMT -6) I take a Zometa infusion every 30 days, however before they give it to me I have blood work done. Denosumab is administered via subcutaneous injection once every 6 months, and zoledronic acid via intravenous infusion once every 12 months. Thes… He wants me to take an infusion of Zometa every six months along with Aromasin (daily) for prevention of reoccurance. F: 39 6 months: 1/24/2010: 4: Osteopenia: After first infusion, experienced mild flu-like symptoms beginning about 24 hours after infusion, lasting about 2 days. Unfortunately, the “solution” to circumvent undesirable side effects with the purpose of increasing compliance, brings about new problems – and they are quite undesirable, to say the least. The zoledronic acid was administered immediately after each cycle of adjuvant chemotherapy in a 4-mg dose by intravenous infusion every 3 to 4 weeks for 6 cycles and then every 3 months … Very important is to remember to take Calcium Citrate (not carbonate) with D, twice a day, with meals every day. In addition to those treatments, half were randomly assigned to receive intravenous infusions of Zometa every six months for three years. Zometa stays in your system at a therapeutic dose for 180 days. In other words, in exchange for the often persistent and ultimately dangerous digestive problems caused by oral bisphosphonates, patients could be subject to other nasty symptoms after a European consensus guidance on adjuvant bisphosphonates for early breast cancer also recommends that IV zoledronic acid (4 mg every 6 months) or oral clodronate (1,600 mg daily) are the preferred agents for preventing recurrence of breast cancer and improving disease outcomes.
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