Blanck, Eneroth, and Jakobssons studied 1678 patients with parotid tumors, and only 13 cases of benign oncocytoma were diagnosed. Oncocytoma of the salivary gland. There are many salivary glands in the lips, cheeks, mouth and throat. Serous and mucinous glands. The in- cidence of oncocytoma varies from 0.5% to 1.2% of all parotid … Five patients had bilateral tumors. • Male:Female = 3-1 • Asymptomatic. • 6th -7th Decades. We report a case of oncocytic carcinoma arising in a parotid gland in a 66-year-old female. Oncocytomas are benign salivary gland tumors composed of oncocytes, cuboidal to columnar epithelial cells with The oncocytoma is composed of a dominant nodule within the parotid gland. Oncocytomas are also seen in the thyroid, parathyroid, salivary glands, and kidneys. 2. The aim of this study was to evaluate the diagnost … Radiographic features CT. Often seen as a well-defined parotid mass showing homogeneous enhancement. title = "Oncocytic neoplasms of the parotid gland: A 16-year institutional review", abstract = "BACKGROUND: Oncocytic neoplasms of the parotid gland are a rare collection of salivary gland tumors that include oncocytosis, oncocytoma, and oncocytic carcinoma. Primary salivary gland neoplasms: primary salivary gland neoplasms-general Benign: basal cell adenoma canalicular adenoma cystadenoma (pending) ductal papilloma keratocystoma myoepithelioma oncocytoma pleomorphic adenoma salivary duct papilloma sclerosing polycystic adenoma sebaceous adenoma / lymphadenoma sialadenoma papilliferum Warthin tumor The parotid gland is the most common site in the head and neck. documented cases of benign oncocytoma of salivary gland origin in the literature. It usually occurs in the parotid gland. Oncocytic tumors rarely affect the major salivary glands, accounting less than 1% of all salivary gland tumours. The submandibular gland is rarely involved. Malignant oncocytoma of the parotid gland is a quite rare tumor, with only 40 cases with unequivocal histological diagnosis reported in the literature. H&E stain. J. Fine needle aspiration c ytology, Oncocytomas, salivary gland tumors Introduction Oncocytic neoplasms encompass tumors of the paro tid glands, and their incidence represents approximately parotid neoplasms [1]. An excisional biopsy of the parotid tumor was performed. This raises the concept of a progression model with a progressive transition between these oncocytic lesions. However, several case reports have documented benign tumors of the parotid gland with facial nerve paralysis. Serous ~90% of gland. Department of Pathology, Provincial Clinical Hospital, Faculty of Medicine, Salamanca, Spain, and the Martinez Anido Hospital Diseases of the Thorax, Salamanca, Spain. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Volume 132, Issue 1 , July 2021 , Pages e48-e49 SEGMENTAL ODONTOMAXILLARY DYSPLASIA: A RARE DISORDER Adequate treatment consists of superficial or total parotidectomy (depending on extent and location of the tumor) for parotid … Parotid gland tumor with facial nerve paralysis is strongly suggestive of a malignant tumor. The vast majority of salivary gland oncocytomas occur in the parotid gland. This short video covers the gross and microscopic appearances of oncocytmas arising in the kidney. Parotid: 1.1. REFERENCES 1. FIG. SUMMARY: Parotid gland oncocytoma is an uncommon, benign salivary neoplasm composed of mitochondria-rich oncocytes. There are no known risk factors that contribute to oncoctyomas, although doctors suspect it is a 109, Issue. However, areas of fatty change are noted within the tumor, creating a less cellular appearance . Oncocytomas constitute < 1% of salivary gland tumors and account for about 1% of benign parotid gland neoplasms. Salivary gland diseases (SGD) are multiple and varied in cause.. There is no sex predilection. SUMMARY: Oncocytic neoplasms result from metabolically altered cells that accumulate abundant mitochondria within their cytoplasm by oncocytic metaplasia. 6, p. e72. Patients usually present with a painless, parotid-region mass between the fifth and sixth decades of life. Oncocytoma affects predominantly adults and presents at a mean age of approximately 65 years. While they can affect any of salivary glands. Oncocytic tumors rarely occur in major salivary glands and generally account for less than 1% of all salivary tumors. sia in the salivary glands of patients 70 years of age or older, oncocytic neoplasms are rare in the salivary glands.6 The World Health Organization defines 3 categories of oncocytic neoplasms of the salivary gland. This disambiguation page lists articles associated with the same title. SG (oncocytosis, oncocytoma ) 1. The relative prevalence of the neoplasm in the various salivary gland reflects the abundance of acinic cells: parotid gland (~80%) > minor salivary glands (~17%) > submandibular glands (~3%). Visual survey of surgical pathology with 11104 high-quality images of benign and malignant neoplasms & related entities. salivary gland neoplasms and 82% to 90% of them occur in the parotid gland. Malignant oncocytoma of the parotid gland: a case report with an immunohistochemical and ultrastructural study - Volume 107 Issue 1 Skip to main content Accessibility help We use cookies to distinguish you from other users and to provide you with a better experience on our websites. the parotid gland tends to have benign neoplasms, the submandibular gland 50:50, and the sublingual glands and accessory glands mostly malignant. Parotid oncocytomas account for 1% of all salivary gland tumors. Oncocytoma Oncocytoma Definition Oncocytoma is a benign salivary gland tumor composed of large epithelial cells known as oncocytes. Treatment and prognosis. No cases with intracranial metastasis have been described. Because of its rarity (<1% of salivary gland tumors) and clinical presentation of the tumor, there is a tendency among the clinicians to misdiagnose it as pleomorphic adenoma, hemangioma, or other forms of oncocytosis. Arch Otolaryngol Head Neck Surg 1988;114:898-906. Microscopically, the tumor is seen as solid cords or clusters of tightly packed oncocytes and a thin strand of fibrovascular stroma is … [Article in Italian] Carluccio F(1), Amendola S. Author information: (1)I Clinica Otorinolaringoiatrica, Policlinico Umberto, Università La Sapienza di Roma. Serous demilunes = mucinous gland with "cap" consisting o… Renal tumours with eosinophilic cytoplasm. Pathology. 2.1.2. Oncocytomas are benign salivary gland neoplasms that represent approximately 1.5% of all salivary gland tumors. Such a tumour was diagnosed in the hard palate of a 45 year old female patient and she underwent successful surgical excision. Oncocytes occur as a result of focal oncocytic metaplasia of salivary ductal and acinar cells which is a common finding in old age (above 50 years). See also. It should not to be confused with pancreatic acinar cell carcinoma . Most tumours in this gland are benign. Women and men are involved with similar frequency. Multiple tumors can be associated with syndromic conditions. (2) A62-year-old woman presented with a clinical history of a slowly growing, painless mass in the right parotid gland area. Clinical diagnosis is often challenging due to the likeness of oncocytoma to other benign and low-grade malignant salivary gland tumors. 1. Basal cell adenoma 2. Salivary gland oncocytomas constitute 2.5% of the parotid gland tumors. • Parotid gland is the largest salivary gland • It has the highest incidence of pathology among the major salivary glands – Benign processes far outweigh malignant processes in terms of incidence • Imaging is useful in: – Determining the morphology of parotid lesions and … Salivary gland tumors are variable in location, origin, and malignant potential.. Oncocytic tumours of major salivary glands: a study of 68 cases with follow-up of 44 patients. 3. Typically, patients are older persons (mean age, 61 years), but a broad age range (32 to 87 years) has been reported in the literature. SG (oncocytosis, oncocytoma ) 1. Pathology Location. 2.2. 1.2. Corresponding Author. The tumor cells are oncocytes. Salivary Gland Tumors • Benign • Malignant Relative proportion of malignancy increasing in the smaller glands (rule of thumb is the 25/50/75 rule) 13 14. There have been reports of the coexistence of these oncocytic entities. Salivary gland oncocytomas constitute 2.5% of the parotid gland tumors. Despite the well-recognized morphology of this tumor, there is a wide range of neoplasms that may mimic oncocytoma and hence need to be considered in its differential diagnosis. Serous demilunes = mucinous gland with "cap" consisting of a serous glandular component. Blanck et al. Friday, June 27, 2014. WebPathology is a free educational resource with 11104 high quality pathology images of benign and malignant neoplasms and related entities. Oncocytoma is a rare benign tumour Salivary Gland. The CT features of parotid oncocytomas in the largest … The oncocytes may appear in some tumors as : 1) isolated cells without pathological impor- tance, 2) a more or less large part of the neo- plasm, and 3) cells forming the entire tumor. - Metaplastic and not neoplastic - Location : mostly parotid gland, rarely submandibular, minor salivary gland. We report a rare case of oncocytoma of the submandibular salivary gland. Lesions developing in the minor salivary glands are uncommon, but they do occur. However, its specificity and distribution is not well established. • In less than 10% of cases, oncocytoma and chromophobe RCC may coexist Renal tumors 5. Salivary gland oncocytoma. minor salivary gland of man by Schaffer in 1897. Assistant Professor of Pathology. Metastasizing malignant oncocytoma of the submandibular gland - Volume 112 Issue 1 Oncocytomas are rare benign epithelial tumors, accounting for only 0.5%-1.5% of all salivary gland tumors. A majority of them are seen in middle-age and older adults Generally, the cause of formation of Oncocytomas of Salivary Gland is unknown; however, a past history of radiation exposure to the head and neck region may be a contributory factor, in some cases Dr Matt A. Morgan and Associate Professor Donna D'Souza et al. but remained unchanged for 3 years when the patient died from intercurrent disease. [Parapharyngeal oncocytoma of the parotid gland]. The three main glands: 1. 4 ONCOCYTOMA OF PAROTID GLAND . Oncocytes appear as the principal component in some pathological conditions of the salivary glands including diffuse oncocytosis, oncocytic metaplasia, oncocytoma, oncocytic carcinoma, and multifocal adenomatous oncocytic hyperplasia. Abstract In a histologic re-examination and re-classification of parotid tumors in 1,678 patients treated by surgery, 13 cases of oncocytoma were found. For the most part, clear cell neoplasms of the salivary glands are adenocarcinomas of at least low-grade malignant potential. • Parotid gland is the largest salivary gland • It has the highest incidence of pathology among the major salivary glands – Benign processes far outweigh malignant processes in terms of incidence • Imaging is useful in: – Determining the morphology of parotid lesions and … 2 (top).Several oncocytic foci in salivary gland tissue (H and E, ~24). Disease Entity. In this report, the CT findings are described and correlated with the histopathologic features of a case of oncocytoma involving the parotid gland that arose in a background of nodular oncocytic hyperplasia. Oncocytoma is the benign counterpart of oncocytic carcinoma. Malignant oncocytoma occurred in the parotid gland of a 50-year-old woman. Mucinous ~10% of gland. The majority of these tumors occur in the parotid gland, and few occur in the submandibular gland. Pathology: • Cortical. The incidence of oncocytoma varies from 0.1% to 1.4% of all parotid gland tumors, while oncocytic carcinoma is extremely rate. Mucinous ~10% of gland. Oral Pathology Blog Ads. High-grade oncocytic mucoepidermoid carcinoma of the minor salivary gland origin: a case report with immunohistochemical study. The literature on salivary gland oncocytoma is reviewed. Oncocytes are present that have features of adenocarcinoma. Hum Pathol. Serous ~90% of gland. The aging mitochondrial hypothesis could explain the … They most commonly in the parotid gland (around 80% of cases). Renal Oncocytoma Oncocytic Papillary Renal Cell Carcinoma; Solid, with minimal, poorly developed papillary change: Usually predominantly papillary: At most, rare, focal foamy macrophages: May have clusters of foamy macrophages: Necrosis is rare and only microscopic foci: May have tumor cell necrosis: AMACR/racemase/P504S usually negative Oncocytoma of Salivary Gland is a rare and benign tumor typically arising from the parotid glands (major salivary gland). Oncocytomas represent less than 1% of the salivary gland neoplasms and 82% to 90% of them occur in the parotid gland. 25:523 ( … The parotid gland is the site most often affected, accounting for 78%-84% of salivary gland oncocytomas [12]. Oncocytoma (Benign Oxyphilic Adenoma): • Second most common benign renal tumor. Guarino M, Zuccoli E, Garda E, Cristofori E, Pallotti F, Nebuloni M, Giordano F. Extracellular matrix globules in renal oncocytoma. 3 (bottom).As in Fig. Perineural and intravas-cular invasion, local infiltration and metastatic disease are helpful in diagnosis. 2.Higher magnification of one of the oncocytic foci (H and E, ~53). The tumor is well-circumscribed and it represents approximately 1% of all the tumors affecting this particular part of the body. Oncocytoma of the parotid gland is a rare benign tumor that presents a diagnostic challenge to clinicians. from a benign oncocytoma, or independently, and affects predominantly the parotid gland. Very few cases of parotid oncocytoma have been reported in literature. Ellis GL(1). Acinic cell carcinoma. Only in the third category is the tumor called an oncocytoma. Oncocytoma is a rare benign salivary gland tumour with an incidence rate about 1-2%. Ultrastructural study or immunohistochemical staining using antimitochondrial antibody can confirm the oncocytic nature of the tumor. salivary gland cytology cytology in outline format with mouse over histology previews. 1988 Jul;19(7):862-7. SUMMARY: Oncocytomas of the salivary glands are rare benign epithelial tumors which occur most commonly in the parotid gland. Submandibular: 2.1. DIFFUSE MULTINODULAR ONCOCYTOMA (“ONCOCYTOSIS”) OF THE PAROTID GLAND IRA s. SCHW7ART%, MD,” AND MORION FELDMAN, AIDt A multinodular parotid tumor in a 63-year-old man occupied almost the entire gland and was found to represent diffuse oncocytic growth. Original posting/updates: 1/24/11, 11/27/11. Renal oncocytomas are relatively benign renal tumors. Monomorphic adenomas are benign salivary gland tumors that have a predilection for development in the upper lip and parotid gland. Cells are large and round with nuclear pleomorphism and hyperchromatism. There are benign lesions and are often surgically excised. Visual survey of surgical pathology with 11102 high-quality images of benign and malignant neoplasms & related entities. Parotid tumors are abnormal growths of cells (tumors) that form in the parotid glands. Author information: (1)Department of Oral Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000. Renal oncocytoma is a benign (noncancerous) growth of the kidney. Here we report a case of a giant minor salivary gland oncocytoma mimicking a jaw tumour which was successfully excised along with a … includes only Warthin’s tumour and oncocytoma. WebPathology is a free educational resource with 11102 high quality pathology images of benign and malignant neoplasms and related entities. Strictly defined, oncocytoma is benign In the past, some cases of clear cell carcinoma and chromophobe carcinoma have been included in series of oncocytomas ... Department of Pathology Stanford University School of Medicine Stanford CA 94305-5342 . The oncocytoma was composed of polyhedral cells with fine eosinophilic granular cytoplasm and a rounded nucleus. Brandwein MS, Huvos AG. It is located in the parotid gland in 82% of cases. We evaluate here a case of swelling of the parotid gland in a 70-year-old male who had the tumor … There is no capsule. Salivary Gland Tumors Benign Pleomorphic adenoma Warthin`s tumor Oncocytoma Myoepithelioma Ductal papilomas Monomorphic adenoma 1. The main clinical importance of this lesion is the difficulty in pre-operatively distinguishing it from renal cell carcinomas, as epidemiology, presentation, imaging and even histology can be very similar. Background: Oncocytic carcinoma is a rare malignant tumor of the salivary gland. • Solid mass with stellate scar in 33-54% of tumors . A 61-year-old male presented with pain in his right parotid gland. 2.1.1. Essential to differentiate from mimicker oncocytic renal cell carcinoma entities. One case of oncocytoma and another of oncocytic carcinoma of the parotid gland are reported with ultrastructural studies. From Libre Pathology. Abstract. An ultrastructural study. There are no clear etiologies for most oncocytomas. Renal oncocytoma are benign renal oncocytic neoplasms. Oncocytomas have been postulated to arise from oncocytic hyperplasia. Cells are packed with mitochondria under electron microscopy. Renal oncocytoma. Approximately 84% of major salivary gland oncocytomas occur in the parotid, with the remainder in the submandibular gland. • 10% bilateral- 10% multiple. 16~18*24 According to Hamperl, ” Am J Surg Pathol. 1997 Jan;21(1):1-12. Parotid gland oncocytoma most often presents as a painless mass. DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. Very rare; usually males, tumor of parotid or submandibular gland High grade tumor that arises de novo or in oncocytoma (J Oral Pathol Med 1998;27:225) May occur after radiotherapy (J Exp Clin Cancer Res 1998;17:65) Disease specific 5 year survival of 54% (Oral Oncol 2010;46:773) May recur, have regional / distant metastases (including bone) The purpose of this study was to correlate MR imaging and histopathology of parotid gland oncocytomas and to define the features that may distinguish these neoplasms from other benign and malignant parotid gland tumors. In general, the ratio of benign to malignant tumors is proportional to the gland size; i.e.
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